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Nexium and other PPIs reduce the absorption and concentration in blood of ketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin). Co-administration of Nexium with Clarithromycin increaes area under the plasma concentration time curve (AUC) of the first. Nexium may slow down metabolism of such medications: citalopram, diazepam, clomipramine, phenytoin, imipramine. 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Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment. Nexium increases blood levels of diazepam (Valium) by decreasing the elimination of diazepam in the liver. Nexium and other PPIs reduce the absorption and concentration in blood of ketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin). Co-administration of Nexium with Clarithromycin increaes area under the plasma concentration time curve (AUC) of the first. Nexium may slow down metabolism of such medications: citalopram, diazepam, clomipramine, phenytoin, imipramine. 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