Diflucan is a triazole antifungal medication that is available by prescription that is indicated in the treatment as well as the prevention of fungal infections in the human body. fluconazole diflucan Diflucan is a triazole antifungal medication that is available by prescription that is indicated in the treatment as well as the prevention of fungal infections in the human body. Dosages for Diflucan will vary based on the patient as well as the particular condition that it is being treated for.