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Co-administration of Nexium with Clarithromycin increaes area under the plasma concentration time curve (AUC) of the first. Nexium may slow down metabolism of such medications: citalopram, diazepam, clomipramine, phenytoin, imipramine. Consequently their dose should be corrected. Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets. Nexium is a specific inhibitor of a proton pump (PPIs) of the parietal cells of the mucous layer of stomach. It is a form of Prilosec (Omeprazole). It is accumulated and transformed into an active form in the secretory tubules where it inhibits secretion of hydrochloric acid. Nexium is used to treat gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, promote healing of erosive esophagitis, eradication of Helicobacter pylori together with antibiotics, preventive therapy of ulcers after treatment with anti-inflammatory non-steroid medications. 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